HIV/AIDS患者浅表淋巴结肿大与其CD_4^+T淋巴细胞计数的相关性分析

Relationship between superficial lymphadenectasis and CD_4^+ T-lymphocyte counts in HIV /AIDS patients

目的探讨HIV/AIDS患者肿大浅表淋巴结的病理改变与其CD+4T淋巴细胞计数的相关性。方法对81例HIV/AIDS患者肿大的浅表淋巴结组织进行病理学检查,并检测其外周血CD+4T淋巴细胞计数。结果 CD+4T淋巴细胞<100cells/ul有58例,100～200cells/ul有17例,>200cells/ul有6例。主要病理改变结核病48例,艾滋病相关淋巴结病15例,淋巴结反应性增生14例。合并浅表淋巴结肿大的结核病患者的CD+4T淋巴细胞计数比较差异有统计学意义(P=0.008)。合并淋巴结反应性增生患者的CD+4T淋巴细胞计数比较差异有统计学意义(P=0.018)。结论检测外周血CD+4T淋巴细胞计数对出现浅表淋巴结肿大的HIV/AIDS患者的临床诊断具有重要的参考价值。

Objective To investigate the correlation between pathological changes of lymph nodes and CD4＋ T-lymphocyte counts and superficial lymphadenectasis in HIV/AIDS patients. Methods 81 HIV/AIDS patients with superficial lymphadenoctasis were given lymph node biopsy and accepted peripheral blood CD4＋ T-lymphocyte count detection. Results There were 58 patients with CD4＋ T-lym- phocyte counts lower than 100 cells/μl, 17 patients with CD4＋ T-lymphocyte counts between 100ccns/μl and 200cells/μl and 6 patients with CD4＋ T-lymphocyte counts more than 200cells/μl. The pathological results included 40 cases of tuberculosis, 9 cases of AIDS-related lymphadenopathy and 14 cases of reactive hyperplasia. There was statistical difference of the CD4＋ T-lymphocyte counts in HIV/AIDS pa- tients with tuberculosis （ Fisher, P = 0. 008 ）. Conclusion The major cause of superficial lymphadenopathy in HIV/AIDS patients is in- fection, and the most common cause is tuberculosis. The lower the CD4＋ T-lymphocyte counts, the greater the risk of tuberculosis is. The detection of CD4＋ T-lymphocyte count in peripheral blood might be useful for clinical diagnosis in HIV/AIDS patients with superficial lymphadenoctasis.