高龄肺癌住院患者感染真菌性肺炎的调查研究

Research on elderly patients with lung cancer infected with fungal pneumonia

目的探讨高龄肺癌患者肺部真菌感染发病的特征。方法总结住院继发真菌性肺炎患者64例的临床资料。结果 64例患者痰培养的致病真菌以白色假丝酵母菌为主。患者均用过抗生素治疗,痊愈39.1%(25例),好转42.2%(27例),好转治愈率为81.3%(52例);病死率为18.8%(12例),死亡原因以呼吸衰竭为主。本组临床资料示应用卡泊芬净治疗结束后肝肾功能无明显变化。结论支气管、肺泡及医院真菌感染的高发生率是老年重症肺炎形成的重要因素。

Objective To explore the clinical characteristics of elderly patients with lung cancer complicated with pulmonary fun- gal infection. Methods The clinical data of 64 patients with lung cancer complicated with pulmonary fungal infection were retrospectively summarized. Results The pathogenic fungi mainly were candida albicans. All of them were treated with antibiotics. There were 25 cases cured （39. 1% ） , 27 cases improved （42.2%） , and 12 cases died （ 18. 8% ）. The cause of death was due to respiratory failure mostly. The clinical data had no significant changes in liver and kidney function at the end of caspofungin therapy. Conclusion The important factors causing severe pneumonia are bronchial, alveolar, and hospital fungal infection.