摘要
Compound 1, N-methyl-N-（（2-（p-tolyl）quinolin-4-yl）methyl）aniline （C24H22N2）, as a potential drug for the treatment of acid-related diseases has been synthesized via palladium- catalyzed intramolecular hydroarylation. The compound was characterized by MS and NMR spectra. Meanwhile, the crystal of I was obtained and determined by X-ray single-crystal diffrac- tion. Crystal data： triclinic system, space group P1, a = 5.548（5）, b = 11.545（10）, c = 14.546（12）A, a = 90.427（15）, β = 90.727（14）, γ = 101.099（16）°, V= 914.1（13） A3, Z = 2, F（000） = 360, Dc = 1.230 g/cm3,μ = 0.072 mm-1, R = 0.0564 and wR = 0.1616 for 9768 independent reflections （Rint = 0.0447） and 3003 observed ones （I 〉 2σ（I））.
Compound 1, N-methyl-N-（（2-（p-tolyl）quinolin-4-yl）methyl）aniline （C24H22N2）, as a potential drug for the treatment of acid-related diseases has been synthesized via palladium- catalyzed intramolecular hydroarylation. The compound was characterized by MS and NMR spectra. Meanwhile, the crystal of I was obtained and determined by X-ray single-crystal diffrac- tion. Crystal data： triclinic system, space group P1, a = 5.548（5）, b = 11.545（10）, c = 14.546（12）A, a = 90.427（15）, β = 90.727（14）, γ = 101.099（16）°, V= 914.1（13） A3, Z = 2, F（000） = 360, Dc = 1.230 g/cm3,μ = 0.072 mm-1, R = 0.0564 and wR = 0.1616 for 9768 independent reflections （Rint = 0.0447） and 3003 observed ones （I 〉 2σ（I））.
基金
Supported by the National Natural Science Foundation of China (Nos. 21102084, 21272136 and 31070313)
Scientific and Technological Research Project of Hubei Provincial Department of Education (Q20111210)
Science Foundation of China Three Gorges University (No. KJ2010B001)
