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起搏通道调控外周神经疼痛的机制研究 被引量：2

Study on the mechanisms of pacemaker channel regulating peripheral neuropathic pain
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摘要 运用大鼠幸免神经损伤模型和电生理膜片钳技术,研究了HCN通道在外周神经疼痛中的作用机制.发现疼痛组大鼠DRG神经元上的HCN通道兴奋性显著增强,注射ZD7288可有效抑制这种变化. In this study, we used the spared nerve injury model and patch-clamp technol- ogy, studied the mechanisms of pacemaker channel on regulating peripheral neuropathic pain. Our results showed that the HCN channel excitability in the pain group rats DRG neurons significantly increased. Injecting with ZD7288 can block this effect.
作者 成秋平
机构地区 华中科技大学生命科学与技术学院
出处 《华中师范大学学报（自然科学版）》 CAS 北大核心 2013年第4期547-550,共4页 Journal of Central China Normal University：Natural Sciences
关键词 疼痛模型 HCN通道 DRG 膜片钳 pain model HCN channel DRG patch-clamp
分类号 Q424 [生物学—神经生物学]
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参考文献9

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同被引文献34

  • 1涂会引,姜玉秋,刘风雨,邢国刚,石玉顺,李潭,姚磊,韩济生,万有.蛛网膜下腔注射ZD7288对神经病理痛大鼠机械性痛敏的影响[J].中国疼痛医学杂志,2006,12(4):228-233. 被引量：6
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华中师范大学学报（自然科学版）
2013年 第4期

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