葡聚糖-Fe_3O_4磁性纳米粒子在小鼠体内的分布

The Vivo Distribution of Glucan-Fe_3O_4 Magnetic Nanoparticles in Mice

采用水热法制备葡聚糖-Fe3O4磁性纳米粒子，并建立原子吸收法测定葡聚糖-Fe3O4磁性纳米粒子生物样品定量分析方法，研究其体内分布。小鼠的心、肝、脾、肺、肾中低、中、高3种浓度加样回收率为98．80％～100．41％，日内精密度RSD均小于3％，日间精密度RSD均小于5％，经尾静脉给药后葡聚糖-Fe3O4主要被肝脏摄取。

Dextran-Fe3O4 magnetic nanoparticles were prepared by hydrothermal method. An atomic absorption spectrometry quantitative analysis method was built of dextran -Fe3O4 magnetic nanoparticles in biological samples to study the vivo distribution. The dextran -Fe3O4 magnetic nanoparticles whose diameter was less than 20 nm were prepared, and it was up taken by the liver primarily after intravenous administration via the tail.