间充质干细胞向胰岛样细胞诱导分化的研究进展

Research of the Induction of Mesenchymal Stem Cells into Islet-like Cells

胰岛细胞的移植是最有希望治疗糖尿病的方法之一,近年来研究取得了一些进展,但供体缺乏和免疫排斥仍是限制其发展的两大难题。骨髓间充质干细胞(BM-MSCs)在体外可通过多种方法诱导分化为胰岛样分泌细胞,为细胞移植治疗糖尿病提供了新的思路与方法。近年来,干细胞理论和实验技术得到了进一步发展,通过自体移植同时避免了供体缺乏和免疫排斥两大难题。利用干细胞治疗糖尿病成为临床上最近研究的热点。该文对间充质干细胞向胰岛样细胞分化诱导的现状及研究进展作一综述。

Islet cell transplantation is one of the most promising methods for treatment of diabetes.In recent years,the research has made some progress,while the lack of donors and immunological rejection remain are still the major problems restricting the development.Bone marrow mesenchymal stem cells in vitro can be induced into islet secreting cells through a variety of methods,which provides new ideas and methods by cell transplantation for diabetes research and treatment.In recent years,with the development of stem cell theory and experimental techniques,the two problems are avoided by autologous transplant.Application of stem cells for treatment of diabetes has become a hot research spot recently.Here is to make a review of the current situation and progress of research on induction of mesenchymal stem cells differentiation into islet-like cells.