促甲状腺激素在胰岛素抵抗发生中的作用

The Role of Thyroid-stimulating Hormone in the Pathogenesis of Insulin Resistance

流行病学研究发现,血清促甲状腺激素(TSH)水平与胰岛素抵抗呈正相关。然而,血清TSH水平与胰岛素抵抗之间存在相关性的机制目前尚不清楚。促甲状腺激素受体(TSHR)不仅存在于甲状腺滤泡细胞表面,在前脂肪细胞和脂肪细胞表面同样检测到TSHR的表达。血清TSH可以直接与脂肪细胞表面的TSHR结合,发挥甲状腺以外的效应。血清TSH是否刺激脂肪细胞分泌炎性因子,进而参与胰岛素抵抗的发生,尚有待研究。

Epidemiological studies have shown that serum thyroid-stimulating hormone（TSH） levels are positively related to insulin resistance,though the mechanisms are not clear so far.Since the thyroid-stimulating hormone receptor（TSHR） is not only expressed in thyrocytes but also in preadipocytes and adipocytes.Serum TSH can function outside the thyroid through direct combination with TSHR on the cell surface.Whether TSH contributes to insulin resistance in adipocytes by directly stimulating the production of adipokines still needs further studies.