高同型半胱氨酸血症与缺血性脑血管病的相关性分析

Correlation Analysis of High Homocysteine and Ischemic Cerebrovascular Disease

目的分析并评价高同型半胱氨酸血症和缺血性脑血管疾病间的相关性。方法选择重庆市黔江中心医院收治的中青年脑梗死患者、中青年短暂性脑缺血患者以及体检健康对照者各31例,分析三组血浆同型半胱氨酸水平及高同型半胱氨酸血症的发生率。结果脑梗死组与短暂性脑缺血组血浆高同型半胱氨酸水平显著高于对照组(P<0.01);脑梗死组与短暂性脑缺血组高同型半胱氨酸血症发生率显著高于对照组(P<0.01)。结论同型半胱氨酸水平上升是造成动脉粥样硬化性缺血性脑血管病的独立危险因子,血浆同型半胱氨酸血症可作为中青年存在脑血管疾病倾向的常规检测指标,具有重要的参考价值。

Objective To analyze and evaluate the correlations between hyperhomocysteinemia and ischemic cerebral vascular disease.Methods Selected from Chongqing Qianjiang District Center Hospital,31 cases of young patients with cerebral infarction,31 cases of transient cerebral ischemia and 31 normal controls were analyzed by plasma homocysteine levels and incidence of hyperhomocysteinemia.Results Plasma homocysteine content of cerebral ischemia group and transient cerebral ischemia group was significantly higher than that of control group（P 0.01）;hyperhomocysteinemia incidence of cerebral infarction group and transient cerebral ischemia group was significantly higher than that of control group（P 0.01）.Conclusion Homocysteine level rise is an independent risk factor causing atherosclerotic ischemic cerebrovascular disease,and plasma homocysteine is of great importance as a routine test index for cerebrovascular disease tendency in youth,which has important reference value.