丹栀逍遥丸对多囊卵巢综合征治疗的研究

Research of Danzhi Xiaoyao Wan in the Treatment of Polycystic Ovary Syndrome

目的观察丹栀逍遥丸治疗肝郁火旺型多囊卵巢综合征(PCOS)无排卵的临床疗效及作用机理。方法选择符合肝郁火旺型PCOS高雄激素血症的研究对象60例,随机分为2组,治疗组30例,对照组30例。治疗组口服丹栀逍遥丸+复方醋酸环丙孕酮(达英-35);对照组口服达英-35。治疗3个周期后口服来曲唑+(或不+)肌内注射尿促性素诱发排卵,比较两组患者的血清促黄体生成素(LH)、睾酮(T)、排卵率、周期排卵率,促性腺激素失调等情况,评价其临床疗效。结果 1.在相同的促排周期中加服丹栀逍遥丸可提高患者的排卵率(P<0.05)及排卵周期(P<0.05)。2.两组患者治疗后血清LH值、T值均较治疗前低,差异有统计学意义(P<0.05)。3.治疗组的肝郁火旺证候有所改善。结论丹栀逍遥丸联合达英-35改善月经,促进排卵,并且能改善肝郁火旺证的中医证候,而单用西药则没有此优势。

Objective To observe the clinical efficacy and effect mechanism of Danzhi Xiaoyao Wan on polycystic ovary syndrome（PCOS） differentiated as liver qi stagnation and excessive fire.Methods Sixty subjects of hyperandrogenemia in PCOS differentiated as liver qi stagnation and excessive fire were selected and randomized into two groups,a treatment group（30 cases） and a control group（30 cases）.In the treatment group,Danzhi Xiaoyao Wan ＋ Compound Cyproterone Acetate（Diane-35） were prescribed for oral administration.In the control group,Diane-35 was prescribed for oral administration.In the treatment of 3 cycles,the oral administration of letrozole combined with / without intramuscular injection of menotrophin was applied to induce ovulation.The levels of serum luteinizing hormone（LH）,testosterone（T）,ovulation rate and cycle ovulation rate as well as gonadotropin disorder were compared in the patients between the two groups.The clinical efficacy was assessed.Results 1.In the same cycle of ovulation induction,with Danzhi Xiaoyao Wan supplemented,the ovulation rate（P 0.05） and the cycle of ovulation（P 0.05） were improved.2.After treatment,LH and T values in serum were all lower as compared with those before treatment in the patients of the two groups,indicating the statistical significant difference（P 0.05）.3.The symptoms of liver qi stagnation and excessive fire in the treatment group were relieved.Conclusion Danzhi Xiaoyao Wan combined with Diane-35 promotes menstruation and ovulation and relieves the symptoms of liver qi stagnation and excessive fire differentiated in traditional Chinese medicine.The advantages of this medication cannot be achieved by simple western medication.