外阴上皮内瘤样病变

Vulvar Intraepithelial Neoplasia

随着外阴癌发病率上升,发病年龄年轻化,外阴上皮内瘤样病变(VIN)作为癌前病变受到更多关注。阐述VIN病因学及分类、病理特征、临床特点、治疗方法、复发及恶化。VIN治疗方法目前缺乏统一标准,治疗目的是去除病灶、预防恶变、保留功能。治疗后复发是临床常见问题。虽然手术是解决该病主要手段,但免疫疗法、光动力疗法、聚焦超声治疗有助于保留外阴结构和功能,易于为患者接受。咪喹莫特是一种有前景的保守治疗药物,人乳头瘤病毒(HPV)疫苗接种将成为预防寻常型VIN的有力措施。

With the vulvar cancer increases in incidence and younger age of onset,vulvar intraepithelial neoplasia lesions are more concerned about as precancerous lesions.This paper describes the vulvar intraepithelial neoplasia lesions of the etiology and classification,clinical features,pathology character,treatment progress and treatment options,recurrence and progression.The therapeutic approach for vulvar intraepithelial neoplasia is variours.The objectives of treatment are not only e liminating lesions to prevent development of invasive vulvar cancer,but also including preservation of normal vulvar function and anatomy.The recurrence,even after extensive surgical procedures,are common.Surgical excision is currently the standard treatment for vulvar intraepithelial neoplasia,The new treatment modalities,including immunotherapy,focused ultrasound therapy and photodynamic therapy,are easy accepted by patients because of the effectiveness and maintaining relatively normal-appearing and functioning anatomy.Imiquimod is possibly an alternative to currently available methods of treatment.Vac cine against Human Papillomavirus is going to be a dominant modality to prevent vulvar intraepithelial neoplasia.