延时摄像在人类辅助生殖技术中的应用

Time-lapse in Human Assisted Reproductive Technology

体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)是广泛应用于不孕治疗的人类辅助生殖技术之一。由于单次促排卵治疗可以获得多个胚胎,临床上如何选择具有发育潜能的胚胎进行移植,以保证在一定临床妊娠率的前提下减少移植胚胎数目,一直是辅助生殖技术研究的一大热点。目前评价胚胎质量的方法主要是选取特定的时间点观察胚胎,依据形态学指标对胚胎质量进行评估。而近年来出现的胚胎延时摄像技术(time-lapse)能够对胚胎体外发育过程进行全程监控,获取胚胎发育的动态信息,建立胚胎行为学指标从而更有效地评估胚胎的发育潜能。延时摄像技术在临床上的应用优势正在逐渐彰显。

One of the most extensively used methods in human assisted reproductive technology（ART） is in vitro fertilization-embryo transfer（IVF-ET）.Due to the multiple embryos obtained per ovulation induction treatment,how to select the most potential embryo for clinical transfer in order to guarantee clinical pregnancy rate and simultaneously reduce the number of transferred embryos remains the hotspot in ART area.At present,embryo evaluation is based on morphology,which is static.The newly developed time-lapse technology is available to monitor the whole development process so as to more precisely evaluate the embryo quality.And its advantages are gradually manifested.