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一种新型T1-T2双模磁共振造影剂的制备及性能研究

Preparation and properties study of a new type of T1-T2 dual mode MRI contrast agent
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摘要 研究了Fe_3O_4@SiO_2@Gd_2O(CO_3)_2核/壳/壳磁性纳米粒子,作为一种新型的T1-T2双模磁共振成像造影剂.并对这种纳米粒子的细胞活性进行了体外细胞毒性试验(MTT).结果显示其具有良好的生物相容性,有望成为一种新型双模磁共振造影剂. This paper studied the Fe3O4@SiO2@Gd2O（CO3）2 core/shell/shell NPs as a new type of T1-T2 dual model contrast agent for magnetic resonance imaging.The magnetic coupling between Fe3O4@SiO2@Gd2O（CO3）2 was modulated by the separating SiO2 layer to produce appropriate T1 and T2 signal.The Fe3O4@SiO2@Gd2O（CO3）2 NPs exhibit good biocompatibility, showing great potential for biomedical applications.
作者 高礼鹏 刘凯 罗春花 李建奇 王依婷 彭晖
机构地区 华东师范大学科学与技术跨学科高等研究院 华东师范大学极化材料与器件教育部重点实验室 华东师范大学物理系
出处 《华东师范大学学报（自然科学版）》 CAS CSCD 北大核心 2013年第5期102-109,共8页 Journal of East China Normal University(Natural Science)
基金 国家自然科学基金(60976004) 上海市重点基础项目(11JC1403800) 上海市教委创新项目(12ZZ041)
关键词 Fe3O4@SiO2@Gd2O(CO3)2核 壳 壳纳米粒子 双模磁共振造影剂 生物相容性 Fe3O4@SiO2@Gd2O（CO3）2 core/shell/shell NPs dual model contrast agent biocompatibility
分类号 O469 [理学—凝聚态物理]
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参考文献19

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华东师范大学学报（自然科学版）
2013年 第5期

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