尿微量白蛋白肌酐比值、血胱抑素C在2型糖尿病肾病中的临床应用

Clinical application of urinary albumin excretion rate and serum cystatin C the in type 2 diabetic nephropathy patients

目的:探讨尿微量白蛋白肌酐比值与血胱抑素C在2型糖尿病肾病中的临床应用。方法:选取我院内分泌科2011年8月～2012年4月住院的2型糖尿病患者85例进行研究,根据尿微量白蛋白排泄率是否正常将其分组。检测尿微量白蛋白肌酐比值、血胱抑素C,观察指标间的相互关系。结果:尿微量白蛋白排泄率增高组与尿微量白蛋白排泄率正常组比较,尿微量白蛋白肌酐比值、血胱抑素C均有显著性差异(P<0.05)。尿微量白蛋白肌酐比值和尿微量白蛋白排泄率呈正相关(r=0.793,P<0.05)。胱抑素C和尿微量白蛋白排泄率呈正相关(r=0.529,P<0.05)。结论:尿微量白蛋白肌酐比值、胱抑素C在临床上可做为糖尿病肾病的监测指标。

Objective：To explore the clinical application of microalbuminuria creatinine ratio （mAlb/Cr） and serum cystatin C the in type 2 diabetic nephropathy patients.Methods： 85 cases with type 2 diabetes from August 2011 to April 2012 were included .The patients were divid- ed into two groups according to urinary albumin excretion rate （UAER）. mAlb/Cr and Cys C were detected. The correlation among the indi- cators were observed. Results： The mAlb/Cr and Cys C levels between the two groups were significantly different （P〈0.05）;mAlb/Cr and UAER were positively correlated（r=0.793, P〈0.05 ） ;Cys C and UAER were positively correlated（r=0.529, P〈0.05 ）. Conclusions： The mAlb/ Cr and Cys C levels can be used as monitoring index of type 2 diabetic nephropathy.