血管紧张素Ⅱ受体拮抗剂对实验性肾小球硬化的作用

Effects on AngⅡ receptor antagonist on experimental glomerulosclerosis

目的 :观察血管紧张素Ⅱ受体拮抗剂氯沙坦对 5 / 6肾切除大鼠残余肾组织肾小球硬化的影响。方法 :将5 / 6肾切除鼠分为氯沙坦治疗组和对照组 ,并设假手术组为正常对照组。检测各组术后第 2 ,4,6周的尿蛋白及第 6周的血清尿素氮、肌酐、总蛋白、白蛋白 ,并观察第 6周肾组织病理改变。结果 :氯沙坦治疗组与对照组相比 ,尿蛋白排泄量明显减少 (P <0 .0 1) ,血肌酐、尿素氮水平下降 (P <0 .0 1) ,肾小球增生、硬化程度明显减轻。结论 :氯沙坦可减轻5 / 6肾切除鼠的肾功能损害 ,延缓残余组织肾小球硬化的进展。

Objective: To observe the effects of angiotensin Ⅱ receptor antagonist losartan in experimental glomeruloscoerosis. Methods: The 5/6 nephrectomized rats were randomly divided into losartan treatment group and control group, the rats with sham operation served as normal control. Urine proteins were measured in the 2nd, 4th and 6th week after operation, and serum BUN, creatineine, total protein and albumin were measured in the 6th week following operation. Renal pathologic changes were evaluated in the 6th week. Results: Losartan not only reduced urine protein, serum creatinine and BUN(P<0.01), but also significantly ameliorated glomerular mesengial proliferation and glomerular sclerosis. Conclusion: The results suggest that losartan can retard progression of glomerulosclerosis in 5/6 nephrectomized rats. [