晚期前列腺癌的外照射治疗

External irradiation treatment of prostate cancer at late stage

目的 :研究晚期前列腺癌的外照射治疗的疗效。方法 :1993年 3月— 1999年 3月共收治晚期前列腺癌 45例 ,C期 32例 ,D期 13例 ,对所有病例均予外照射治疗 ,局部肿瘤量达 5 5— 70Gy 5 .5— 7周。结果 :所有病例放疗后排尿困难、骨转移疼痛改善 ,血尿消失 ,放疗后血前列腺特异性抗原 (PSA)均明显下降 ,为 0 0 1— 2 8ng ml,平均 0 35ng ml,放疗后 9个月复查局部肿瘤消失 2 9例 ,明显缩小 16例 ,随访 10个月— 72个月 ,发现病灶消失无复发病例 ,血PSA始终能保持在 0 5ng ml以下 ,75 %在 0 2ng ml以下。结论 :晚期前列腺癌的外照射治疗可以缓解症状 ,提高生存率 。

Purpose:To study the efficacy of the external irradiation treatment of prostate cancer at the late stage.Methods:Totally 45 cases of late stage prostate cancer patients received from Mar.1993 to Mar.1999. 32 cases are in stage C and the other 13 cases are in stage D. External irradiation treatments were performed on all the patients, local tumor doses were up to 55—70 Gy/5.5—7 weeks.Results:After radiotherapy, all cases were improved as to dysuria and bone metastasis pain, their haemuresis disappeared, and the blood prostate specific antigen (PSA) declined markedly to 0.01—2.80 ng/ml, to 0.35 ng/ml on average. 9 months later, countercheck of the all the cases was done and found local tumor being disappeared on 29 cases and became markedly smaller in 16 cases. From 10th to 72nd month, in several cases the lesson had disappeared and no recurrences. Furthermore, their blood PSA continued to be under 0.5 ng/ml all along, 75% cases were even under 0.2 ng/ml.Conclusions:The external irradiation treatment of prostate cancer can allariate symptoms raise survival rate. The blood PSA is considered to be the most valuable tumor marker for prostate treatment results' monitoring and prognosis judgement.