P-选择素及其配体与肿瘤转移关系的研究进展

Advances in the research of P selectin and it's ligands in tumor metastasis

肿瘤转移为恶性肿瘤致死和临床治疗远期疗效较差的主要因素 ,细胞粘附为转移过程的关键步骤之一。有关研究表明P 选择素 (P selectin)及其配体与肿瘤浸润、侵袭和转移灶形成有关 ,并有可能成为肿瘤转移的预后指标和肿瘤标志。但P selectin及其配体与肿瘤转移的关系 ,尤其是血小板P

Purpose:Tumor metastasis is the main cause of tumor death and poor long term effect in clinical treatment. In the process of metastasis, tumor cell adhesion is one of the key steps. It has been shown that P selectin and its ligands were related to tumor infiltration, invasion and the generation of metastastic lesions, and may be a prognostic factor or metastasis index. But the relationship between platelet P selectin and tumor emboli/metastasis need to be further investigated.