介入法治疗激素性股骨头坏死的临床和实验研究

A Clinical and Experimental Study of Intercurrent Treatment for Glucocorticord-induced Necrosis of Femoral Head

目的 :探讨介入治疗股骨头坏死的作用机理。方法 :临床方面收治激素性股骨头坏死 3 6例 ,年龄2 2～ 62岁。共 52髋。应用中西药物介入治疗。每髋 2次 ,每次间隔 2周。 3 4例获完整随访 ,平均随访时间 1 3个月。采用 1 994年全国股骨头坏死专题会议标准。Ficat ～ 期 ,优良率 91 %。实验中用新西兰大白兔 56只 :造模组 ( 40只 )和空白对照组 ( 1 6只 )。建立兔激素性股骨头坏死模型后 ,将动物分为两组 ,治疗组及对照组。结果 :介入治疗后血管中断现象改善 ,小血管数目增多。空骨陷窝率低 ,有新生的血管组织。结论 :介入疗法是治疗早期激素性股骨头坏死的有效方法。

clinical study:Thirty six admitted patients (52hips)suffering glucocorticord induced ncerosis of femoral head were treated with cagtheterization and perfusion of traditional Chinese medicine and Western medicine in the medial and lateral femoral circumflex arteries.Thrity four cases were followed up with a average of 13 months.Acording to the criteria established in the national meeting of bone necrosis in 1994,the rate of excellent and good results was 91% in Ficat stage 1～2.(2)experimental study:56 adult rabbits were divided into two groups randomly.The normal control group was 16 rabbits and the glucocorticoid model group was 40 rabbits which were divided two groups,ie,treated group and modelcontrol group.All animals were performed the experiment simultaneously.The results showed that the blood vessels of treated group were increased and regenerated and it's rate of empty lacunae of bone tissues was lower than modelcontrol group.The study comfirmed that intercurrent treatment has a remarkable effect to ANFH in ficat stage 1～2.