摘要
目的 探讨促甲状腺素释放激素 (Thyrotropin releas inghormone ,TRH)对烧伤休克大鼠氧自由基所引起的脂质过氧化损伤的作用。方法 复制大鼠 40 %TBSAⅡ°烧伤休克动物模型 ,烧伤后 0 5h给予TRH(5mg·kg-1体重 ) ,观察烧伤前后平均动脉压的动态变化 ,烧伤后生存时间 ,烧伤后1、3、5h血浆、心、肝、肺、肾SOD活力和MDA含量的变化。结果 TRH能提高烧伤休克大鼠的血压并维持在高水平 ,明显抑制生命器官组织MDA含量的上升 ,提高SOD活力 ,大鼠的生存时间明显延长。结论 TRH在抗大鼠烧伤休克的同时 ,具有良好的抗脂质过氧化损伤作用 ,适合于烧伤早期应用。
Objective To determine the effects of thyrotropin-releasing hormone (TRH) on peroxidation in burnt shock rats. Methods A 40% TBSAⅡ degree burnt rat model was used, and TRH was intra-arterial infused (5 mg·kg -1) 05 h postburn. The dynamic changes of mean arterial pressure (MAP) and the survival time were observed. Blood and tissue specimens were taken at 1,3 and 5 h after scald. The content of malondialdehyde (MDA), activity of superoxide dismutase (SOD) in plasma, heart, liver, lung and kidney were examined. Results Along with the administration of TRH, the MAP raised, the activities of SOD in plasma and organs ascended, the contents of MDA in plasma and organs reduced, and the survival time prolonged. Conclusion TRH has antishock effects and attenuated oxygen free radical-induced lipid peroxidation in burnt shock rats, recommended for the early postburn stage.
出处
《安徽医科大学学报》
CAS
2000年第4期269-271,共3页
Acta Universitatis Medicinalis Anhui
