载脂蛋白E基因型与脑叶出血的关系

The Relationship between Apolipoprotein E Genotype and Lobar Intracerebral Hemorrhage

目的 探讨载脂蛋白E(apoE)基因型与脑叶出血的关系。 方法 用PCR技术检测 2 6例脑叶出血apoE的基因型 ,并与 30名健康同年龄对照组和 30例基底节脑出血组比较。结果 脑叶出血组ε4 等位基因频率明显高于健康对照组 (P <0 .0 5 ) ,且脑叶出血组E3/3基因型有下降趋势 ;而基底节出血组apoE基因型与ε4 等位基因频率和健康对照组比较没有显著性差异 (P >0 .0 5 )。结论 ε4 等位基因有较高的脑叶出血风险 ,而与非脑叶出血无关。

Objective To explore the relationship between apolipoprotein E (apoE) genotype and lobar intracerebral hemorrhage (ICH).Method The polymerase chain reaction (PCR) technique was used to detect apoE genotype in 26 patients with lobar ICH,30 matched controls and 30 matched patients with basal ganglia ICH.Results The frequency of allele epsilon 4 (ε 4) was 0.214 in the lobar ICH group,which was significantly higher than that of 0.08 in the normal control group ( P <0.05).There was a tendency to a lower frequency of genotype E3/3 in the lobar ICH group.We found no significant diffrences in apoE genotype and the frequency of ε 4 allele between basal ganglia ICH group and control group.Conclusion It suggests that allele ε 4 indicates a higher risk of lobar ICH and has no relationship with non lobar ICH.