不同剂量右旋美托咪啶对高血压患者全麻复苏期的应用

目的观察手术结束前注射不同剂量右旋美托咪啶对高血压患者全麻复苏期的影响。方法选择患有原发性高血压需气管插管全麻行普外科或妇科择期经腹手术病例90例，ASAI～Ⅱ级。随机分为三组（n=30）。手术结束前15min分别注射不同剂量DEX（B组和C组）或生理盐水（A组）。记录手术结束时（TO）、拔管前（Y1）、拔管后即刻（T2）、拔管后3min（T3）、送出手术室时（T4）等各时相的BP、HR、BIS等。记录各组患者拔管和送出手术室的平均耗时。记录各组在复苏期的不良反应病例。结果B、C组在麻醉复苏期，特别是拔管前后的血压和心率波动均低于A组。同时B组的副反应例数低于A、C组。结论手术结束前15min静脉注射0．5汕g／kg的DEX可以安全有效的用于高血压患者全麻复苏期，改善复苏质量。

Objective To Observe the effect on hypertensive patients treated with different doses of dexmedetomidine during the recovery period after general anesthesia. Methods 90 hypertensive patients who were scheduled for elective general surgery or gynecological operation under general anesthesia were randomly divided into 3 groups,with 30 patients in each group Patients in derrerent groups were injected with defferent doses dexemdetomidine or normal saline in 15 min before the end of the operations. BP, HR and BIS were detected in the end of the opertation（T0）, before extubation（T1）, after extubation immediately（T2）, at 3rain after extu- bation （T4） and before leaving PACU（T4）.Time of extubation, staying PACU and side effects during the periods were recored. Results BP and HR of group B and C were more stable than group A during the recovery period especially in the extuation period.The number of cases of side effects in group B was less than in group A and C Conclusion It is safety and availability for hypertensive patients that injection of dexmedetomidine 0.5 μg/kg in 15min before the end of the operation.