自体巩膜条翻转引流青光眼滤过术的实验研究

Experiment of turning scleral flap of self body over drainage in trabeculectomy of glaucoma

目的 证明自体巩膜条翻转引流在青光眼小梁切除术后有保持滤过道畅通的作用。方法 健康成年家兔 2 5只 ,用自体巩膜条做为引流物 ,在巩膜瓣下引流 ,同一只家兔另一只眼做经典的小梁切除 ,进行滤过泡、眼压及组织学观察。结果 术后第 1～ 2周 ,实验组眼压低于对照组 ,差异无显著性 (P>0 .0 5 )。术后第 3～ 12周 ,实验组眼压明显低于对照组 (P<0 .0 5 )。术后第 2～ 7周 ,实验组功能性滤过泡存留比率明显高于对照组 (P<0 .0 5 )。结论 自体巩膜条翻转引流在小梁切除术后保持滤过功能。

Objective To investigate the effect of turning scleral flap of self body over drainage in trabeculectomy.Methods The surgery was performed on one eye of a rabbit while the other eye of the same rabbit was conducted with the routine trabeculectomy as the control group. The filtering bleb, intraocular pressure and pathology were observed. Results The intraocular pressure in the experimental eye was much lower than that in the control group 3～12 weeks after the operations ( P <0 05).As it was within 2 weeks after the surgeries, but there was no significant filtering difference ( P >0.05).The rate of eyes with functional bleb in the experimental group was significantly higher than that in the control group at the postoperative 2～7 weeks .Conclusion This study suggests the turning of self body over drainage surgery can help to maintain filtering function for a long time and to prevent complication after filtering surgery.