期刊文献+

盐酸美金刚中间体I的合成 被引量:2

Synthesis of Memantine Hydrochloride Intermediates I
下载PDF
导出
摘要 以1,3-二甲基金刚烷和液溴为原料,不加任何溶剂,40℃反应24h,高收率,高纯度的生成盐酸美金刚重要中间体1-溴-3,5-二甲基金刚烷。 Taking 1,3 - dimethyl adamantane and liquid bromine as the raw material, stirred at 40℃ for 24h without any solvent. The reaction generated 1 - bromo -3 ,5 - dimethyladamantane, with highyield and high purity.
出处 《山东化工》 CAS 2013年第8期3-4,共2页 Shandong Chemical Industry
关键词 盐酸美金刚 中间体 合成 memantine hydrochloride intermediates synthesis
  • 相关文献

参考文献7

  • 1Abdel - Aal Raafat A, Assi Abdel - Azim A, Kostandy Botros B. Memantine prevents aluminum - induced cogni- tive deficit in rats[ J]. Behavioural Brain Research, 2011 , 225 (1) :31 -38.
  • 2Jouni Ihalainen , Timo Sarajarvi, Doug Rasmusson, et al. Effects of memantine and donepezil on cortical and hipp- ocampal acetylcholine levels and object recognition memory in rats [ J ]. Neuropharmacology, 2011,61 ( 5/6 ) : 891 - 899.
  • 3Kovacic P, Roskos P D. New synthetic approach to me- mantine hydrochloride starting from 1,3 - dimethyl - ada- mantane [ J ]. J Am Chem Soc, 1969,91:6457 - 6460.
  • 4Sasaki T,Eguchi S,Katada T,et al. An improved synthesis of memantine hydrochloride : ? anti - alzheimer drug[ J ]. J org Chem, 1977,42:3741 - 3743.
  • 5Mills J, Krumkalns E. Adamantyl secondary amines: US, 3391142 [ P]. 1968 - 07 - 02.
  • 6Scherin A, Homburg B, Peteri D, et al. Drugs or medicines for influencing the central nervous system: US, 4122193 [ P]. 1978 - 10 - 24.
  • 7Gerzon K, Krumkalns E , Brindle R L, et al. A compari- son of the predictive therapeutic and undesired side - effects of the NMDA receptor antagonist, memantine, in mice[J]. J Med Chem,1963( 6): 760-763.

同被引文献7

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部