妊娠妇女及新生儿脐血瘦素水平与体重、胰岛素、C-肽、胰岛素样生长因子-Ⅱ的关系

Study on the Relationships between Leptin Levels and Weights of Mothers and Infants and the Relationships of Cord Serum Leptin to C-peptide,Insulin and Insulin Like Growth Factor-Ⅱ

目的 探讨妊娠晚期妇女及新生儿脐血瘦素水平与孕妇体重及新生儿体重的关系 ,以及新生儿脐血瘦素水平与C 肽、胰岛素、胰岛素样生长因子 Ⅱ (IGF Ⅱ )等的关系。方法 采用放射免疫法测定 5 0例孕 37～ 38周正常妊娠妇女 (研究组 )及其新生儿、2 9例健康未妊娠妇女 (对照组 )的血瘦素水平 ,并同时测定新生儿脐血C 肽、胰岛素、IGF Ⅱ的水平等。结果 (1)妊娠晚期妇女血瘦素水平为 (13.6 2± 3.6 8) μg/L ,明显高于对照组妇女的 (6 .6 0± 3.0 4) μg/L及新生儿脐血瘦素的 (8.0 5± 4.6 1) μg/L。 (2 )妊娠晚期妇女血瘦素水平与本身体重及体重指数明显相关 (r分别为 0 .33、0 .35 ,P<0 .0 5 ) ;妊娠晚期妇女血瘦素水平与新生儿体重无明显相关 (r=0 .10 ,P >0 .0 5 )。 (3)新生儿脐血瘦素水平与其体重、体重指数明显相关 (r分别为 0 .5 4、0 .49,P <0 .0 0 1) ;而与妊娠晚期妇女血瘦素水平无明显相关 (r=0 .19,P >0 .0 5 )。 (4 )对照组妇女血瘦素水平与其体重、体重指数明显正相关 (r分别为 0 .72、0 .78,P <0 .0 0 1)。 (5 )新生儿脐血C 肽为 (0 .86± 0 .35 ) μg/L ,胰岛素为 (8.49± 4.76 )mU/L ,IGF Ⅱ为 (0 .2 18± 0 .0 76 ) μg/L ;新生儿脐血瘦素水平与C 肽明显相关 (r=0 .37,P <0 .0 5 )

Objective To determine the relationships between serum leptin levels and maternal weights in late pregnancy and cord blood leptin levels to birth weights, C peptide, insulin and insulin like growth factor (IGF II). Methods Fifty normal pregnant women at 37～38 weeks and their newborns were studied, and 29 non pregnant women were set as control. Venous blood was taken from women and from the cord at delivery. Blood leptin and cord blood C peptide, insulin, and IGF II were measured by radio immunoassay. Results The average leptin level in maternal sera was (13.62±3.68)μg/L, significantly higher than that in the control (6.60±3.04)μg/L and that in cord blood (8.05±4.61)μg/L. Maternal leptin levels were significantly correlated with maternal weights and body mass index (BMI. r =0.33, 0.35, P <0.05), but not with infant birth weights ( r =0.10, P >0.05). Cord blood leptin levels were significantly correlated with birth weights and BMI ( r =0.54, 0.49, P <0.001) but have no correlation with maternal leptin levels ( r =0.19, P >0.05). Significant difference of the cord leptin levels was not seen between the males and females. The cord blood C peptide was (0.86±0.35) μg/L, insulin (8.49±4.76) mU/L and IGF Ⅱ(0.218±0.076) μg/L. Cord leptin levels were correlated with C peptide levels ( r =0.37, P <0.05),but not with insulin and IGF Ⅱlevels ( r =0.19, -0.14, P >0.05). Conclusions Maternal leptin levels in late pregnancy were significantly higher than those in normal non pregnant women and positively correlated with maternal weights and BMI. Cord blood leptin levels were positively correlated with birth weights and BMI of the newborns. The leptin levels of cord blood were correlated with those of C peptide but not insulin and IGF II.