高压氧治疗突发性聋的再评价

A reappraisal of hyperbaric oxygenation effect and study on serum maiondialdehyde and superoxide dismntase in patients with sudden deafness

目的 观察突发性聋高压氧 (hyperbaricoxygenation ,HBO)治疗前后血清脂质过氧化物代谢产物丙二醛 (maiondialdehyde ,MDA)和超氧化物歧化酶 (superoxidedismntase ,SOD)的浓度变化及对高压氧治疗效果的影响。方法 6 0例 79耳突发性聋的患者 ,随机分为综合组 30例 43耳和单纯组 (单纯高压氧组 ) 30例 36耳 ,另有 30名健康志愿者做正常组。治疗前后比较听力变化 ,用硫代巴比妥酸法检测MDA、用放射免疫法检测SOD。结果 2组治疗后听力比较 ,差异有显著性意义 ( χ2 =6 .48,P<0 .0 5 )。SOD测试 :综合组治疗后与正常组、单纯组比较 ,差异均有非常显著性意义 (前者t=2 3 2 7,P <0 .0 1,后者t =2 7.17,P <0 .0 1) ;综合组治疗前后比较 ,差异有非常显著性意义 (t =2 9.2 7,P <0 .0 1) ;单纯组治疗前后比较 ,差异无显著性意义 (t=1.33,P >0 .0 5 )。MDA测试 :综合组与单纯组治疗后比较 ,差异有非常显著性意义 (t=8.86 ,P <0 .0 1) ;综合组治疗前后比较 ,差异有非常显著性意义 (t=7.2 8,P <0 .0 1) ;综合组治疗后与正常组比较 ,差异无显著性意义 (t=1.2 4,P >0 .0 5 ) ;单纯组治疗后与正常组比较 ,差异有非常显著性意义 (t=7.0 9,P <0 .0 1)。结论 单纯高压氧治疗突发性聋的治愈率极低。

Objective To reappraise the effect of HBO and to observe the changes of maiondialdehyde (MDA) and superoxide dismntase (SOD) in serum of the patients with sudden deafness. Methods 60 patients were randomly divided into two groups. One was treated with HBO combined with medical treatment (treatment group). The other was only treated with HBO (control group). There were 30 healthy volunteers as health group. Results After treatment, there was a significant difference (χ2=6.48, P<0.05) in patient's groups in hearing examination. After treatment, SOD volume in treatment group had significant difference with health group and control group (t=23.27, P<0.01; t=27.17, P<0.01) respectively. There was a significant difference of SOD volume in treatment group itself before and after treatment course (t=29.27, P<0.01). There was no significant difference of SOD volume in control group itself before and after treatment(t=1.33, P>0.05). MDA: There was a significant difference between treatment group and control one after the treatment. There was a significant difference (t=7.28, P<0.01) in treatment group before and after treatment course . There was not a significant difference (t=1.24, P>0.05) between treatment and health group after the treatment course. There was a significant difference (t=7.09, P<0.01) between control group and health one after the treatment course. Conclusion There was no satisfied curative effect on sudden deafness with HBO only.