腹腔镜手术配合米非司酮治疗子宫内膜异位症疗效观察

The Clinical Efficacy of Laparoscopic Surgery Combined with Mifepristone in Treatment of Endometriosis

目的:观察腹腔镜手术配合米非司酮口服治疗子宫内膜异位症(EM)的临床效果。方法:选取本院2010年1月-2012年1月收治的EM患者88例,随机分为对照组与观察组,其中对照组单纯行腹腔镜手术,观察组于术后服用米非司酮,比较两组患者临床疗效及不良反应发生情况。结果:观察组总有效率明显高于对照组,差异有统计学意义(P<0.05);观察组术后复发率明显低于对照组,而术后妊娠率高于对照组,比较差异均有统计学意义(P<0.05);观察组无严重不良反应发生,且两组不良反应发生率比较无显著性差异(P>0.05)。结论:腹腔镜手术配合米非司酮治疗EM效果明显优于单纯腹腔镜手术治疗,且临床复发率低,不良反应少,可明显提高患者妊娠机会。

Objective：To observe the clinical efficacy of laparoscopic surgery combined with mifepristone in treatment of endometriosis（EM）. Method：88 cases of patients with EM admitted to our hospital from January 2010 to January 2012 were randomly divided into the control group and the observation group,the control group was given laparoscopic surgery,and the observation group was given mifepristone on the basis of the control group. The clinical efficacy and adverse events were compared between the groups.Result：The total efficiency of the observation group was significantly higher than the control group,the difference was satistically significant（ P 0.05）;postoperative recurrence rate of the observation group was lower than the control group,and pregnancy rate was higher than the control group,there were significant differences between the groups（ P 0.05）;there were no serious adverse reactions of the groups,and incidence of adverse reactions both groups showed no significant difference（ P 0.05）.Conclusion：The laparoscopic surgery combined with mifepristone in treatment of EM has good effect and it has low clinical recurrence rate,fewer adverse reactions,the patients can significantly improve the pregnancy chance.