持留菌的研究进展

Research progress of persisters

细菌的耐药性一直是细菌感染性疾病治疗的最大障碍。除了基因突变产生的耐药外，还存在一种难以被常规或高浓度的药物杀灭，但耐药性没有遗传的数量极少的耐药亚群。这一亚群在抗生素压力降低后，部分细菌又可以繁殖再生，同时对之前的抗生素保持敏感，并与被杀灭的细菌保持同源性，这些细菌就被称为持留菌。此文就持留菌的形成机制、种类、清除方法及其与耐药菌的关系等最新的研究进展进行了综述。

Bacteria resistance is the biggest obstacle of bacterial infections disease treatment. Despite some drug resistant bacteria produced by genetic mutation, there is a small amount of multidrug-tolerant subgroup which is hardly killed by antibiotic at normal or high concentration, and keeps no genetic resistance. When the antibiotic concentration reduced, some bacteria of this subgroup can reproduce, and remain sensitive to prior antibiotic at the same tL, ne, and keep homology with the other killed bacteria of this subgroup, these bacteria are called persisters. In this article, the latest research processes about the formation mechanism, different types, elimination methods of persisters and its relationship with drug resistance bacteria are reviewed.