难辨梭状芽孢杆菌在炎症性肠病中的研究进展

Clostridium diicileinfection in patients with inflammatory bowel disease:An update

炎症性肠病(inflammatory bowel disease,IBD)的病因有很多,其中微生物因素近来越来越受到关注.研究发现难辨梭状芽孢杆菌感染(Clostridium difficile infection,CDI)在成人及儿童IBD患者中的发生率不断上升.抗生素、免疫抑制剂、抑酸剂等药物可增加IBD患者发生CDI的风险,及时检测CDI并选择有效的抗生素是治疗重点,同时可辅以免疫及生态治疗.本文对难辨梭状芽孢杆菌在炎症性肠病中的研究进展作一综述.

Inflammatory bowel disease （IBD） has many eti- ological factors, among which microbial factors have attracted more and more attention recently. Studies have demonstrated that the incidence of Clostridium difficile infection （CDI） in both adult and children IBD patients has been rising in recent years. Many drugs such as antibiotics, im- munosuppressive agents, and acid-suppressing agents may increase the incidence of CDI. Iden- tifying CDI and selecting effective antibiotics are keys to successful treatment, and immunological and ecological treatments are also useful choices. In this article, we will review the progress in re- search of CDI in IBD patients.