激动κ阿片受体在改善高脂血症引起的血管内皮功能失调中的作用机制探讨

Improvement effect of κ-opioid receptor on hyperlipidemia-induced endothelial dysfunction

高脂血症引起的血管内皮功能失调是引起代谢综合征及多种心血管疾病并发症的关键环节之一。高脂血症造成血管内皮损伤的机制包括导致血管内皮分泌的血管舒、缩因子平衡失调、促进炎症反应和促进血管内皮氧化应激等。同时,激动κ阿片受体(κ-opioid receptor,κ-OR)在多种心血管疾病研究中被证实可以起到明确的心血管保护作用,但关于激动κ-OR在高脂血症引起的血管内皮功能失调中的作用仍有待研究。本文综述了高脂血症导致的血管内皮损伤和激动κ-OR所起的血管内皮保护作用的研究进展,探讨了激动κ-OR在改善高脂血症引起的血管内皮功能失调中的作用,为进一步研究激动κ-OR所起的作用提供了思路。

Endothelial dysfunction induced by hyperlipidemia is recognized as one of the pivotal factors in the pathogenesis of metabolic syndrome and a variety of cardiovascular complications. Mechanisms involved in hyperlipidemia-induced endothelial dysfunction include the imbalance between the secretion of vasoconstrictor and vasodilator, vasculitis and up-regulated oxidative stress in endothelial cells. Many studies have proved that the activation of κ-opioid receptor （κ-OR） has some cardiovascular protective effect. However, the role of κ-OR in hyperlipidemia-induced endothelial dysfunction is still unclear. This paper reviews the current knowledge about hyperlipidemia-induced endothelial dysfunction and the cardiovascular protective effect of κ-OR activation on hyperlipidemia-induced endothelial dysfunction.