microRNA在肺动脉高压形成中的作用被引量：2

Roles of microRNA in pulmonary arterial hypertension

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摘要微小RNA(microRNA)是真核细胞内源性表达、高度保守、长度约为22个核苷酸的非编码RNA,可以调控基因的表达,与众多疾病的发生发展有关。近期研究发现,多种microRNAs表达失调在肺动脉高压(pulmonary arterial hypertension,PAH)及多种心血管疾病的发展中起重要作用,其成为新的分子生物学标志并有广泛的治疗应用前景。本文就microRNA在PAH中的作用作一综述。 MicroRNAs are endogenously expressed and highly conserved non-coding RNAs which regulate gene expressions in eukaryons. Recent studies have found that the dysregulation of some microRNAs plays an important role in pulmonary arterial hypertension （PAH） and some other cardiovascular diseases. MicroRNAs thus become novel biomarkers of these diseases and show potentials of clinical applications. This review focuses on the roles of microRNAs in PAH.

作者赵施皓杨智伟郑煦暘冯娜李娟裴建明

机构地区第四军医大学口腔医学系第四军医大学基础部生理学教研室

出处《心脏杂志》 CAS 2013年第4期494-498,共5页 Chinese Heart Journal

基金国家自然科学基金项目资助(30900535 30971060 31100827 81270402 31200875) 陕西省攻关课题项目资助(2010K01195) 陕西省自然科学基金项目资助(2011JM4001)

关键词肺动脉高压微小RNA 内皮细胞血管平滑肌细胞 pulmonary arterial hypertension microRNA endothelial cells vascular smooth muscle cells

分类号 R543.2 [医药卫生—心血管疾病]

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