生长因子及其在短肠综合征中的应用

Growth Factors and Their Application in Treatment for Short Bowel Syndrome

目的探讨生长因子促进大量肠切除后肠道代偿的作用与机制,并了解其在短肠综合征营养支持治疗中的研究进展。方法对介绍生长因子促进肠切除后肠道代偿以及其在短肠综合征患者的应用的有关文献进行综述。结果不同种类的生长因子对促进肠切除后肠道代偿产生着不同的效应,可根据短肠综合征患者的具体情况合理选择外源性生长因子,以缩短残留小肠代偿时间,改善患者的营养状况。结论生长因子能够在一定意义上促进肠切除后肠道代偿,但不同种类的生长因子有各自的作用效应,将对短肠综合征患者尽早摆脱完全肠外营养有帮助,但仍需进一步的研究。

Objective To investigate the effect and mechanism of growth factors on intestinal compensation after massive intestinal resection,and understand the progress of growth factors in nutrition support treatment for short bowel syndrome（SBS）.Method The related literatures about the application and effect of growth factors in the patients with SBS were reviewed.Results Different kinds of growth factors had different effects on intestinal adaptation after massive intestinal resection.The application of growth factors according to the specific circumstances of the patients with SBS could shorten the residual small intestine compensatory time and improve the nutrition status of the patient with SBS.Conclusions Growth factors play important role in promoting the intestinal adaptation after resection.Different kinds of growth factors have their effects and it’s helpful for getting rid of the total parenteral nutrition early.However,much work still remains to be done.