参松养心胶囊和稳心颗粒及盐酸胺碘酮片治疗慢-快综合征的临床疗效对比研究

Comparative Study on the Curative Effect of Shensongyangxin Capsule and Wenxin Particles and Amiodarone Hydrochloride Tablets in the Treatment of Slow-fast Syndrome

目的对比参松养心胶囊、稳心颗粒、盐酸胺碘酮片治疗慢-快综合征临床疗效的异同。方法将96例慢-快综合征患者随机分为A组、B组、C组3组,每组均为32例。A组口服参松养心胶囊,B组口服稳心颗粒,C组口服盐酸胺碘酮片,均治疗3周。用药前后行常规12导联心电图和24h动态心电图检查。结果 A、B两组缓慢心律失常心电图改善情况、快速心律失常心电图改善情况及临床疗效比较,差异无统计学意义(P>0.05);A、B两组上述指标分别与C组比较,差异有统计学意义(P<0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05),不良反应症状轻微,均不需要停药。结论参松养心胶囊、稳心颗粒治疗慢-快综合征均可有效改善心电图表现,缓解临床症状,且不良反应少,是治疗慢-快综合征较为理想的药物选择,值得临床推广应用。

Objective To compare theclinical efficacy of Shensongyangxin capsules, Wenxin particles and Amioda- rone hydroehloride tablets in the treatment of slow - fast syndrome. Methods 96 eases of slow - fast syndrome were randomly di- vided into group A, group B, group C, each 32 eases, group A was given Shensongyangxin capsules orally; Group B was given Wenxin particles orally; Group C was given Amiodarone hydrochloride tablets orally, all were treated for three weeks, line 12 - lead ECG and dynamic ECG 24h were checked before and after medication. Results The slow arrhythmia ECG improvement, rapid arrhythmia ECG improvement and clinical curative effect of groups A, B were comparied, the difference were not statisti- cally significant （ P 〉 0.05 ） ; The above indicators of group A, B respectively compared with group C, the difference was statis- tically significant （ P 〈 0. 05）. The incidence of adverse reactions of 3 groups were comparied, there was no statistically signifi- cant difference （P 〉 0.05 ）, adverse reaction are mild, without discontinuation. Conclusion Shensongyangxin capsules and Wenxin particles in the treatment of slow - fast syndrome can be effective in improving ECG showed, remissing the clinical symp- toms, and fewer side effects, which are the ideal drug of choice for treatment of slow - fast syndrome, worthy of clinical applica- tion.