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脂联素与胰岛β细胞功能关系的研究进展 被引量:1

Research Progress in Relationship between Adiponectin and Function of Pancreatic β-cell
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摘要 脂联素是由脂肪细胞分泌的一种重要肽激素,能够调节新陈代谢和能量平衡。脂联素可引起脂肪酸氧化、促进葡萄糖摄取,并在肌肉和肝脏中抑制糖异生,由此改善胰岛素的敏感性。此外,脂联素还有抗动脉粥样硬化及抗炎作用。大多数研究集中于脂联素在骨骼肌、肝脏和脂肪组织中的作用,而对脂联素与胰岛β细胞之间关联的可靠研究结果相对较少。该文旨在阐述脂联素与胰岛β细胞间的复杂关系。 Adiponectin is one important peptide hormone secreted by adipocytes involved in the regula- tion of metabolism and energy homeostasis. Adipanectin induces fatty acid oxidation and glucose uptake, and suppresses gluconeogenesis in muscle and liver, thereby improving peripheral insulin sensitivity. In addition, adiponectin has antiatherogenic and anti-inflammatory properties. Most studies have focused on the action of adiponectin in skeletal muscle,liver, and adipose tissue, whereas relatively fewer results are available regard- ing the "cross talk" between adiponectin and 13-cells. The purpose of this review is to investigate the complex relationship between pancreatic 13-cells and adiponeetin.
作者 白宇娜 闻颖
出处 《医学综述》 2013年第17期3073-3075,共3页 Medical Recapitulate
基金 国家自然科学基金(81172650)
关键词 脂联素 胰岛Β细胞 胰岛素分泌 Adioonectin : Islet 13-cells : Insulin secretion
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  • 1柏家林,蔡葵蒸.脂联素及其受体基因研究进展[J].两北民族大学学报:自然科学版,2012,33(1):35-40.
  • 2俞匀,朱大龙.脂联素及其受体研究进展[J].医学研究生学报,2005,18(9):841-844. 被引量:6
  • 3Brown JE, Conner AC, Digby JE, et al. Regulation of beta-cellviability and gene expression by distinct agonist fragments of adipone- ctin[ J]. Peptides,2010,31 (5) :944-949.
  • 4Wijesekara N, Krishnamurthy M, Bhattacharjee A, et al. Adiponectin- induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secre- tion[ J]. J Biol Chem,2010,285 (44) :33623-33631.
  • 5自加吉,邓刚.脂联素研究进展[J].四川解剖学杂志,2010,18(2):27-31. 被引量:5
  • 6王适龙,钟惠菊,盛杰,王静.球形脂联素对胰岛β细胞胰岛素分泌和凋亡的影响[J].中国糖尿病杂志,2010,18(12):930-933. 被引量:8
  • 7Okamoto M, Ohara-Imaizumi M, Kubota N, et al. Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration [ J ]. Diabetologia,2008,51 ( 5 ) : 827-835.
  • 8Winzell MS, Nogueiras R, Dieguez C,et al. Dual action of adipone- ctin on insulin secretion in insulin-resistant mice [ J ]. Biochem Biophys Res Commun ,2004,321 ( 1 ) : 154-160.
  • 9赵荷珺,李兴.脂联素与胰岛素抵抗的研究进展[J].医学研究杂志,2010,39(9):126-129. 被引量:6
  • 10朱晓岩,王建国,王晓旭,刘磊,邓清华,李东娜,王哲,刘国文.脂联素的最新研究进展[J].中国畜牧兽医,2010,37(12):60-63. 被引量:4

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