摘要
树突状细胞(DC)起源于CD34+造血祖细胞,是目前已知功能最强大的专职抗原呈递细胞(APC),其在器官移植后可通过多种机制诱导与维持机体对移植物的免疫耐受。随着对DC诱导免疫耐受机制研究的日渐深入,其作用途径也渐为人知。肝脏是已知的免疫特惠器官,具有独特微环境及多种免疫学特性,亦含有大量的DC。该文就DC诱导肝移植耐受的相关研究进展予以综述。
Dendritic cell（DC） is the most powerful dedicated antigen presenting ceil（APC） known so far,which originates from CD34＋ hematopoietic progenitors. It can induce and maintain body＇s immune toler- ance for graft after organ transplant through a variety of mechanisms. DC＇s functioning mechanisms are gradu- ally known to us along with the deepening research. The liver is an immune privilege organ with unique microenvironment and many kinds of immunological characteristics, which contains lots of DC. Here is to make a review of the latest progress of DC induce immune tolerance after liver transplant.
出处
《医学综述》
2013年第17期3082-3085,共4页
Medical Recapitulate
基金
国家自然科学基金(30960378)
关键词
树突细胞
肝移植
免疫耐受
Dendritic cells
Liver transplant
Immune tolerance
