摘要
阿尔茨海默病(AD)是一种常见的中枢神经系统变性疾病,其病理特征主要是在海马和颞叶皮质出现老年斑和神经纤维缠结。大量研究表明神经纤维缠结与Tau蛋白过度磷酸化有关,而β-淀粉样蛋白(Aβ)是老年斑的主要成分。大量临床和流行病学证据表明AD的发病有性别差异,绝经后的老年女性更容易发生AD,说明雌激素缺乏是AD的危险因素。因此,雌激素替代治疗AD日益受到人们的重视,该文就近年有关雌激素与AD神经保护机制及其替代治疗进行综述。
Alzheimer disease（AD） is a common degenerative diseases of the central nervous system, and its main pathological features is senile plaques and neurofibrillary tangles in the hippocampus and temporal cortex. Numerous studies show that the neurofibrillary tangles is related to Tau protein hyperphosphorylation, and B-amyloid（ AB） is the main component of the senile plaques. A large number of clinical and epidemiological evidence show that there is a gender difference in the incidence of AD, women are more likely to develop AD after menopause, which indicates the lack of estrogen is a risk factor of AD. So people are paying more attention to estrogen replacement therapy for AD. Here is to make a review of AD neuroprotective mech- anism and hormone replacement therapy of estrogen.
出处
《医学综述》
2013年第17期3095-3097,共3页
Medical Recapitulate
关键词
雌激素
阿尔茨海默病
神经保护机制
激素替代治疗
Estrogen
Alzheimer disease
Neuroprotection mechanism
Hormone replacement therapy
