摘要
鼻咽癌是高度恶性的肿瘤,伴随局部浸润和早期远处转移。鼻咽癌的病因主要包括遗传易患性、地方环境因素和EB病毒感染。一旦发生转移,预后很差,所以,迫切需要找到早期临床诊断、预后的生标志物和新的有效的治疗靶点。新近研究表明,原钙黏蛋白(PCDH)8、PCDH17、RRAD等因表观遗传学改变导致基因在鼻咽癌中失活,这些抑癌基因的失活可能与鼻咽癌的发生、发展有关。去甲基化治疗以及表观遗传学联合治疗在血液系统肿瘤及有些实体肿瘤中取得了可喜的进展,有望开拓鼻咽癌治疗的新天地。
Nasopharyngeal carcinoma（NPC） is a highly malignant tumor, accompanied by local inva- sion and early distant metastasis. The etiology of NPC includes genetic predisposition,local environmental factors and EB virus infection. Once transferred, the prognosis is poor, so there is an urgent need to find early clinical diagnosis, prognostic markers and new effective therapeutic targets. Recent studies have shown that PCDH8, PCDHI7, RRAD gene inactivated by epigenetic change in NPC may be associated with the development of nasopharyngeal carcinoma. Demethylation treatment and epigenetic combination therapy have made encouraging progress in hematological malignancies and some solid tumors, which is expected to open up a new world for nasopharyngeal carcinoma treatment.
出处
《医学综述》
2013年第17期3126-3128,共3页
Medical Recapitulate
关键词
鼻咽癌
甲基化
抑癌基因
原钙黏蛋白8
原钙黏蛋白17
Nasopharyngeal carcinoma
Methylation
Tumor suppressor gene
Protocadherin8
Protocadherin17
