培美曲塞治疗腹部肿瘤的临床应用进展

Advances in Clinical Application of Pemetrexed for Abdominal Tumors

培美曲塞是新型多靶点叶酸拮抗剂,通过抑制生成嘧啶和嘌呤的几个关键酶干扰DNA与RNA合成。目前研究发现,培美曲塞对多种实体肿瘤生长具有抑制作用,包括恶性胸膜间皮瘤、非小细胞肺癌、胰腺癌、结直肠癌、胃癌和乳腺癌等,其主要不良反应为骨髓抑制、皮疹、黏膜炎等。该文就培美曲塞单独用药或联合其他药物治疗常见腹部肿瘤的临床应用进展予以综述。

Pemetrexed is a novel multitargeted antifolate that inhibits several enzymes critical for thymi- dine and purine synthesis,and their inhibition,in turn, disrupts DNA and RNA synthesis. Pemetrexed posses- ses antitumor activity in several solid tumors, including malignant pleural mesothelioma, non-small cell lung cancer,pancreas cancer,colorectal cancer,gastric cancer, and breast cancer etc.. The main toxicities of the pemetrexed are myelosuppression,skin rash,and mucositis. Here is to make a review of the clinical application progress of pemetrexed as a single agent or in combination with other drugs for common abdominal tumor.