疏肝解郁胶囊联合文拉法辛治疗老年抑郁症的临床分析

The Efficacy of Shugan Jieyu Capsule Combined with Venlafaxine in Treatment of Senile Depression

目的探讨疏肝解郁胶囊联合文拉法辛治疗老年抑郁症的临床疗效。方法选取2010年6月至2012年6月来新乡医学院第二附属医院就诊的60岁以上的抑郁症患者118例,采用简单随机化法将患者分为对照组和观察组,每组59例。对照组给予文拉法辛缓释片治疗,观察组在此基础上给予疏肝解郁胶囊治疗。疗程为6周。观察并比较两组患者治疗前后的临床疗效、汉密尔顿抑郁量表(HAMD)评分、抑郁自评量表(SDS)评分及不良反应量表(TESS)评分。结果观察组和对照组治疗后的总有效率分别为91.53%和84.75%,两组患者疗效比较有统计学意义(P<0.05);两组患者治疗后HAMD及SDS评分显著低于治疗前(P<0.05)。随着用药周期的增加,HAMD及SDS评分降低显著;与对照组相比,观察组治疗2周后HAMD及SDS评分显著优于对照组(P<0.05);观察组的不良反应数及TESS评分显著低于对照组(P<0.05)。结论疏肝解郁胶囊联合文拉法辛治疗老年抑郁症的临床效果显著,不良反应少,值得在临床推广。

Objective To explore the clinical curative effect of Shugan Jieyu capsule joint venlafaxine as the treatment of senile depression. Methods From June 2010 to June 2012,118 patients of greater than 60 years old with depression from the Second Affiliated Hospital of Xinxiang Medical University were selected and randomly divided into the control group and observation group, 59 patients in each group. The control group was given venlafaxine treatment ,the observation group was added with Shugan Jieyu capsule. The clinical curative effect of the two groups, Hamilton depression rating scale （ HAMD ）, self-rating depression scale （SDS） score and the side effects scale （TESS） rating after six weeks were observed and compared. Results The total effective rate of the observation group was 91.53% after treatment, of the control group was 84.75 %. So, there was significant difference between the two groups （ P 〈 0.05 ） , and SDS and HAMD scores reduced obviously with the increase of drug use cycle. Compared with the control group, HAMD and SDS score of the observation group were much better after two weeks treatment（ P 〈 0.05 ） ; adverse reactions and TESS score of the observation group were significantly lower than the control group（ P 〈 0.05 ）. Conclusion The clinical effect of Shugan Jieyu capsule combined with venlafaxine as treatment for senile depression is remarkable with fewer side effects,which is worth of wide application in clinical.