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MMP-2及其抑制剂在上皮性卵巢癌中的表达及意义 被引量：3

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摘要 目的:探讨基质金属蛋白酶-2(MMP-2)及其在上皮性卵巢癌中的表达水平及其与预后的关系。方法:利用免疫组化方法检测64例上皮性卵巢癌组织中MMP-2及其抑制剂基质金属蛋白酶组织抑制剂-2(TIMP-2)表达水平,并结合临床病理及随访资料进行分析。结果:在卵巢恶性肿瘤组织中的MMP-2及其TIMP-2阳性表达率明显高于卵巢良性肿瘤组织和正常组织(P=0.001),其表达水平与卵巢恶性肿瘤的临床病理特征具有相关性(P<0.05)。COX模型多因素分析显示MMP-2的表达是影响卵巢癌预后的独立因素(P<0.05)。结论:MMP-2表达与卵巢癌转移发展关系密切,可作为预测卵巢上皮性癌预后的可靠指标。
作者 吴东波 杨静 姚雅丽 周庆
机构地区 湖南省妇幼保健院 中南大学湘雅医学院
出处 《临床医药实践》 2013年第9期650-652,共3页 Proceeding of Clinical Medicine
关键词 卵巢肿瘤 基质金属蛋白酶 基质金属蛋白酶组织抑制剂 免疫组织化学
分类号 R735.34 [医药卫生—肿瘤]
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参考文献10

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共引文献25

同被引文献40

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引证文献3

二级引证文献7

临床医药实践
2013年 第9期

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