金环蛇蛇毒对S180,EAC腹水癌细胞的细胞毒性作用

Inhibitory Effects of Bungarus faciatus Venoms on Sarcoma 180 and Ehrilich Asciters Carcenoma in Mice

目的 探讨金环蛇毒对 S1 80 ,EAC腹水癌细胞的细胞毒性作用。 方法 采用小白鼠腹腔和皮下接种 S1 80 ,EAC腹水癌细胞造成小白鼠腹水模型后腹腔注射金环蛇毒。 结果 腹腔注射金环蛇毒 ,能抑制肿瘤细胞的生长 ,降低接种率。但不能完全控制腹水和癌细胞的生长。体外试验表明有明显的细胞毒作用。台酚蓝染色镜检可见死细胞显著增加 ,腹水图片检查给药后细胞膜破裂 ,纤维化坏死明显。 结论 能延长小白鼠存活时间。

Objective To study the inhibitory effects of Bungarus faciatus venoms on sarcoma 180 and ehrilich asciters carcenoma Methods Making up models by inoculating sarcoma 180 and ehrilich asciters carcenoma in mice, and then intraperitoneally injecting or subcutaneously injecting Bungarus faciatus venoms Result This experiment results show that the Bungarus faciatus venoms can obviously inhibit sarcoma 180 and ehrlich ascites carcenoma in mice Conclusion The Bungarus faciatus venoms can prolong the survival times of decreasing the number of tumor mice after inoculation