催化抗体研究新进展

Recent Advances in Abzyme Studies.

催化抗体也叫抗体酶 ,是具有催化活性的免疫球蛋白 .由于它兼具抗体的高度选择性和酶的高效催化性 ,因而催化抗体制备技术的开发预示着可以人为生产适应各种用途的 ,特别是自然界不存在的高效催化剂 ,对生物学、化学和医学等多种学科有重要的理论意义和实用价值 .综述了催化抗体研究的最新进展 ,讨论了该领域目前存在的问题 ,提出了解决这些问题的可能办法 .

Catalytic antibody (also known as abzyme) is a kind of immunoglobulin with catalytic activity. Because it has high selectivity and amazing diversity as antibodies and highly catalytic activities as enzymes, it is anticipated that using abzyme preparation technology one can obtain any kind of tailor made biocatalysts, including those not occurred in nature, for various kinds of practical applications. Thus, abzyme study has an important value in theory and practice for biology, chemistry and medicine etc. The new advances of catalytic antibody research are summarized with a special emphasis on the breadth and scope of new antibody catalyzed reactions and novel hapten design strategies. The problems to be solved in this field are discussed and the strategies for solving these problems are presented with special focus on increasing the catalytic activities of abzymes.