Ras-GTP-Raf复合物及其信号传导的分子机制

Ras-GTP-Raf Complexes and Its Molecular Mechanism in the Signal Transduction.

Ras GTP Raf复合物是RTKs介导的Ras通路的一个关键环节 ,在Ras GTP Raf复合物中信号传递的分子机制是Ras GTP Raf复合物作为一个整体开关信号传导、启动信号放大级联反应及可能导致肿瘤发生 .此外 ,PKC介导的Raf的激活也必需有Ras GTP Raf复合物的存在 .

Ras GTP Raf complexes play an important role in the RTKs mediated Ras pathway. The molecular mechanism of signal transduction in the Ras GTP Raf complexes is that the complexes switch signal transduction, trigger signal amplification cascade and may be involved in neoplasia. In addition, Ras GTP Raf complexes are essential in the PKC mediated activation of Raf.