摘要
目的探讨慢性HBV携带者肝脏组织中白细胞介素12(IL-12)的表达及其意义。方法应用SP免疫组织化学法检测100例慢性HBV携带者肝脏组织中IL-12的表达情况,并与HBeAg、HBV DNA定量分析比较。结果 HBeAg阳性的携带者中IL-12阴性表达率高,HBeAg阴性者IL-12阳性表达率高(r=0.324,P=0.001);HBV DNA水平低者IL-12阳性表达率高,HBV DNA水平高者IL-12阴性表达率高(r=-0.445,P=0.000);免疫耐受者IL-12阴性表达率高,低或非复制期者IL-12阳性表达率高(r=0.569,P=0.000)。结论 IL-12参与HBV感染的慢性化进展与转归。
Objective To investigate the expression levels oflL-12 in the liver of HBV carders and explore its significance. Methods IL-12 expression was detected by immunohistochemistry SP method in liver tissues of HBV carriers （n = 100）. Results The levels of IL-12 in HBeAg positive HBV carriers were significantly lower than those patients with HBeAg negative （r = 0.324, P = 0.001）. The levels oflL-12 in HBV carders with high HBV DNA were significantly lower than those patients with low HBV DNA （r = -0.445, P = 0.000）. The levels of IL-12 in immune-tolerance carriers were lower than inactive carriers （r = 0.569, P = 0.000）. Conclusion IL-12 may be involved in the chronic infection of HBV, the progress and prognosis of the disease.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2013年第3期17-20,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
国家自然科学基金资助项目(No.81072342)
