儿童肺炎支原体感染状况临床分析

Analysis of infection conditions on Mycoplasma pneumoniae in children

目的总结商丘市儿童肺炎支原体（MP）的感染状况，检测血清抗-MP的阳性率。方法采用酶联免疫吸附法对1217例患儿的血清进行MPIgM、IgG抗体检测。结果1217例患儿中MPIgM抗体的比率为19．88％（242／1217），IgG抗体阳性率为16．76％（204／1217），MPIgM和IgG抗体均为阳性的比率为12．65％（154／1217）。〈1岁、1～3岁、3～6岁和〉6岁年龄组MPIgM抗体阳性率分别为14．46％（35／354）、21．07％（51／411）、23．14％（56／236）和41．32％（100／216）；MPIgG抗体阳性率分别为15．20％（31／354）、33．33％（68／411）、23．04％（47／236）和28．43％（58／216）；MPIgM和IgG抗体同时阳性的阳性率分别为17．53％（27／354）、26．62％（41／411）、29．87％（46／236）和25．97％（40／216）。不同性别之间抗，MP阳性率差异无统计学意义（χ2=0．004；P=0．948）；春、冬两季较夏、秋两季的抗-MPI阳性率高，差异具有统计学意义（χ2=133．073；P=0．000）。结论MP是儿童肺部感染的主要病原体之一，应引起高度重视。肺炎支原体的检测根据病情合理选取标本，且其感染率与患儿年龄无关。

Objective To investigate the infection conditions of Mycoplasma pneumonia （MP） among the children in Shangqiu City, and to detect the positive rates of MP antibodies in serum. Methods Enzyme-linked immunosorbent assay （ELISA） was applied to detect MP IgM and IgG antibodies in serum of 1217 children with respiratory infection. Results The positive rates ofMP IgM and IgG antibodies among the children were 19.88% （242/1217） and 16.76% （204/1217）, respectively. The positive rate of MP IgM antibody combined with MP IgG antibody was 12.65% （154/1217）. In uncer one-year-group, 1-3 year-group, 3-6 year-group and 〉 6 year-group, the positive rates ofMP IgM antibody were 14.46% （35/354）, 21.07% （51/411）, 23.14% （56/236） and 41.32% （100/216）, respectively; the positive rates ofMP IgG antibody were 15.20% （31/354）, 33.33% （68/411）, 23.04% （47/236） and 28.43% （58/216）, respectively; the positive rates of MP IgM antibody combined with MP IgG antibody were 17.53% （27/354）, 26.62% （41/411）, 29.87% （46/236） and 25.97% （40/216）, respectively. There were no significant differences between different sexuality （χe = 0.004; P = 0.948）, but the differences between the different seasons was significant （χ2 = 133.073; P = 0.000）. Conclusions MP is one of the major pathogens of pulmonary infection among the children, which should be paid more attention to. The specimen for MP detection should be selected according to the illness The infection rate of mycoplasma pneumoniae had no relationship with age.