MMP22蛋白在喉癌中表达的Meta分析

Meta-analysis of expression and significance of MMP22 in laryngeal carcinoma

目的探讨基质金属蛋白酶22蛋白(MMP22)在喉癌中的表达及临床意义。方法选用Medline、Embase、中国学术期刊网全文数据库、万方数据库和维普数据库等数据库,全面检索国内外已发表的相关文献,最终进入系统评价的病例对照研究文献有7篇。应用Meta分析软件对各研究原始数据进行统计学处理,计算合并OR及95%CI。结果 Meta分析显示,与喉正常组织相比,MMP22蛋白在喉癌中呈高表达[OR=24.30,(95%CI:13.14～44.92),P<0.01];与高分化喉癌中MMP22蛋白对比,中、低分化的喉癌中MMP22蛋白呈高表达[OR=0.24,(95%CI:0.13～0.43),P<0.01];与无淋巴结转移的喉癌相比,伴淋巴结转移的喉癌中MMP22蛋白呈高表达高表达[OR=0.31,(95%CI:0.16～0.57),P<0.01]。结论 MMP22蛋白高表达可能在喉癌的发生、发展及预后中起重要作用。

Objective To evaluate the expression and significance of MMP22 in Laryngeal Carcinoma . Methods With comprehensive retrieval of related literature that had been published in Medeline ,Embase and in China from academic journals collected in CBMdisc and other document database ,there were 7 arti-cles about case-control study which were selected into system to be evaluated .Meta-analysis software Rev-Man5 .1 was used to analyze the raw data and to calculate the value of combined odd ratio （OR） and 95%confidence interval （CI） .Results Meta-analyses showed that MMP22 in laryngeal carcinoma was higher than that of normal laryngeal tissue [OR =24 .30 ,（95% CI ：13 .14 ~ 44 .92） ,P 〈0 .01];M M P22 in mod-erately differentiated laryngeal carcinoma and poorly differentiated laryngeal carcinoma was higher than that of well differentiated laryngeal carcinoma [OR =0 .24 ,（95% CI ：0 .13 ~ 0 .43） ,P〈0 .01];MMP22 in laryngeal carcinoma with lymph node metastasis was higher than that of without lymph node metastasis [OR =0 .31 ,（95% CI ：0 .16 ~ 0 .57） ,P〈0 .01] .Conclusion The high expression of MMP22 may play an important role in progression and prognosis of laryngeal carcinoma .