94例慢性阻塞性肺疾病急性加重期FEV1%、PaO_2、PaCO_2、FIB之间的相关性

94 cases of patients with chronic obstructive pulmonary diseases acute exacerbation period the relevance of FEV1%,PaO_2 ,PaCO_2 and FIB

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者第一秒用力呼气容积占预计值的百分比(FEV1%)、血氧分压(PaO2)、血二氧化碳分压(PaCO2)、血浆纤维蛋白原(FIB)之间的相关性。方法收集新疆医科大学第一附属医院2011年4月-2012年1月通过肺功能及胸部X线片确诊为AECOPD患者94例,其中维吾尔族48例,汉族46例,维、汉两组在年龄、性别、病情严重程度等均有可比性,差异无统计学意义(P>0.05),对94例患者FEV1%、PaO2、PaCO2及FIB进行偏相关分析。结果 AECOPD患者FEV1%与PaO2呈正相关(r=0.64,P<0.01),FEV1%与PaCO2呈负相关(r=-0.89,P<0.01),FEV1%与FIB无相关性(P>0.01),FIB与PaO2呈负相关(r=-0.49,P<0.01)。FIB与PaCO2呈正相关(r=0.39,P<0.01)。结论当患者处于急性加重期,无法耐受肺功能检测时,可通过PaO2、PaCO2作为慢性阻塞性肺疾病急性加重期病情严重程度的判定指标之一,且通过FIB的测定间接了解患者病情严重程度。

Objective To study hospital 94 patients with chronic obstructive pulmonary disease with acute exacerbation （AECOPD） in patients with lung function （FEV1% ） ,blood gas analysis （PaO2 ,PaCO2 ） , and plasma fibrinogen （FIB）between the correlation .Methods Consecutive collected in our hospital from April 2011 to January 2012 diagnosed with chronic obstructive pulmonary disease with acute exacerbation of 94 patients ,48 cases of midterm Uygur ,Han 46 cases ,dimensional ,Han groups in age ,gender ,disease severity were comparable ,and no significant difference （P 〉0 .05） ,partial correlation analysis on 94 pa-tients ,FEV1% ,PaO2 ,PaCO2 and FIB ,and dimensional .Results with AECOPD patients with FEV1%and PaCO2 significantly with a negative correlation （r= -0 .89 ,P〈0 .01） ,FEV1% and PaO2 was signifi-cant with a positive correlation （r = 0 .64 ,P 〈0 .01） ,of FEV1% and FIB without significantly with the relevant （P〉0 .01） ,the FIB and PaO2 was significantly negatively correlated （r= -0 .49 ,P〈0 .01） .FIB and PaCO2 showed a significant positive correlation （r = 0 .39 ,P 〈0 .01） .Conclusion When patients in the acute exacerbation of pulmonary function testing can not be tolerated by blood gas analysis as chronic obstructive pulmonary disease with acute exacerbation of disease severity to determine one of the indica-tors ,and indirectly by the determination of fibrinogen to understand the patient＇s condition severity and prognosis.