甲状腺功能正常的甲状腺相关眼病患者情绪及生活质量的研究

Study on emotions and quality of life in patients with thyroid-associated ophthalmopathy

目的初步探讨甲状腺相关眼病(TAO)对患者焦虑抑郁情绪及生活质量的影响。方法纳入38例甲状腺功能正常的TAO患者及34例健康对照者,以欧洲Graves眼病(GO)专家组(EUGOGO)管理共识为标准将TAO患者分为病情轻度组及病情中重度组,分别运用相关量表对受试者予以焦虑抑郁情绪及生活质量评估。结果 TAO患者焦虑、抑郁发生率分别可达36.8%、28.9%,较健康对照组8.8%、5.9%的发生率显著增高(P<0.05),而TAO患者生活质量评分低于对照组(P<0.01);亚组分析显示女性焦虑、抑郁发生率分别为50.0%、45.5%,显著高于男性18.8%、6.3%的发生率(P<0.05),生活质量评分则低于男性(P<0.05);与TAO病情轻度组相比,病情中重度组焦虑(21.7%vs.60.0%,P<0.05)及抑郁(8.7%vs.60.0%,P<0.01)情绪发生率更高,同时生活质量评分更低(P<0.05)。结论 (1)TAO对患者的情绪及生活质量均有显著影响。(2)TAO患者焦虑及抑郁情绪发生率明显升高,生活质量明显降低;女性患者较男性患者更易出现焦虑及抑郁情绪,生活质量更容易受到TAO影响。(3)TAO患者病情越严重,焦虑抑郁情绪越明显,生活质量越低。

Objective To evaluate the emotions and quality of life in the patients with thyroid-associated ophthalmopathy （TAO）. Methods 38 TAO patients with normal thyroid function and 34 healthy subjects were recruited. The patients with TAO were further divided into the mild and moderate-severe group by EUGOGO criteria. The depressive and anxious status and quality of life of all subjects were assessed by the rating scales. Results The incidence rate of anxiety and depression in the patients with TAO was 36.8~//oo and 28.9~ separately, which were higher than 8.8~ and 5.9% in the controls（P^0.05） ,but the quality of life scores in TAO patients were lower than those in the controls（P^0.05）. The subgroup analysis indicated that the incidence rate of anxiety and depression in female TAO patients was 50.0% and 45.5 ~//0 separately, which were higher than that in male TAO pa- tients 18.8G vs. 6.3^（P^0.05） ,but the quality of life scores in female TAO patients were lower than those in male TAO pa- tients（P^0.05）. Compared with the mild-moderate group, an obviously higher incidence rate of anxiety（21.7 ~ vs. 60.0 %, P~ 0.05） and depression（8.7% vs. 60.0%, P^0. 05） were observed in the severe group with the lower quality of life scores（P~ 0.05）. Conclusion （1） TAO affects the emotions and the quality of life of TAO patients. （2） TAO patients have a statistically higher incidence rate of anxiety and depression and a lower quality of life,this phenomenon is more obvious in female patients. （3） The patients with severe TAO are more likely to have anxiety and depression,as well as a lower quality of life.