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塞来昔布在大鼠痫性发作中的作用及对大鼠认知功能的影响 被引量：2

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摘要 目的:观察COX-2抑制剂-塞来昔布在大鼠痫性发作中的作用及对大鼠认知功能的影响;并从病理学角度观察痫性发作后COX-2及谷氨酸的表达情况以及塞来昔布对其表达的影响。方法:将32只Wistar雄性大鼠按体重随机分为对照组、塞来昔布组(EP-C)、致痫组(EP)。EP-C组大鼠致痫前给予塞来昔布灌胃,然后EP和EP-C组大鼠使用氯化锂-匹罗卡品致痫;比较大鼠痫性发作的持续时间;观察行为以及大鼠海马回内COX-2及谷氨酸的表达情况。结果:3组大鼠均从腹腔注射匹罗卡品后开始观察,根据Racine标准共观察120 min。与EP组大鼠相比,EP-C组大鼠延长了达到癫痫发作的时间,缩短了大鼠癫痫持续状态时间,差异均有统计学意义(P<0.05);EP-C组大鼠海马区的COX-2和谷氨酸的表达较EP组降低。结论:COX-2抑制剂-塞来昔布对癫痫后大鼠的认知功能有一定的保护作用。
作者 耿虹 张佳 马俊兵
机构地区 包头医学院第一附属医院病理科
出处 《包头医学院学报》 CAS 2013年第4期14-16,共3页 Journal of Baotou Medical College
关键词 塞来昔布 痫性发作 COX-2 谷氨酸 认知
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献16

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二级参考文献15

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包头医学院学报
2013年 第4期

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