布托啡诺与舒芬太尼术后自控镇痛的疗效比较

Efficacy Comparison of Butorphanol and Sufentanil on Postoperative Controlled Intravenous Analgesia

目的探讨和比较布托啡诺与舒芬太尼用于术后患者自控静脉镇痛中的临床治疗效果。方法以2011-12/2012-12期间在宜宾市第二人民医院进行腹部手术的114患者作为临床研究对象,随机将其分为布托啡诺组和舒芬太尼组,每组57例。布托啡诺组患者给予酒石酸布托啡诺注射液的术后自控静脉镇痛,舒芬太尼组患者则给予枸橼酸舒芬太尼注射液的术后自控静脉镇痛,比较和分析两组患者术后4 h,8 h,12 h,24 h,48 h的自控静脉镇痛效果。结果与舒芬太尼组相比,布托啡诺组术后8 h、12 h、24 h的视觉模拟评分法(VAS)镇痛评分明显提高,术后4 h,8 h,12 h,24 h的Ramesay评分法镇静评分显著提高,瘙痒、恶心、呕吐、眩晕等不良反应的发生率明显降低,差异均具有统计学意义(P<0.05)。结论布托啡诺可作为术后患者自控静脉镇痛的优选治疗药物。

Objective To compare the clinical effects of butorphanol and sufentanil on controlled intravenous analgesia for postoperative patients. Methods During December 2011 to December 2012,114 abdominal surgery patients were re-cruited and were randomly divided into butorphanol group and sufentanil group, with 57 cases each. The patients in bu- torphanol group were given butorphanol tartrate injection and sufentanil group were given sufentanil citrate injection. The controlled intravenous analgesic and sedative effects at 4h ,8h ,12h ,24h and 48h after surgery of were observed. ResultsCompared with sufentanil group ,the sedation scores of patients in butorphanol group after surgery 8h, 12h and 24h were significantly improve with visual analogue scale, and the improvement was also demonstrated with Ramesay. The inci- dences of itching, nausea, vomiting, dizziness and other adverse reactions were significantly lower for the butorphanol group （ all P 〈 0. 05 ）. Conclusion Butorphanol could be the preferred treatment medicine for postoperative patient controlled intravenous analgesia.