摘要
对抗破伤风毒素人源单克隆抗体G2、G6、G2 +G6与精制破伤风抗毒素进行了中和效力比较试验。结果表明 ,G2、G6二株单抗的中和毒力活性均比精制破伤风抗毒素的高。G2和G6混合后呈完全中和。表明这些人源单抗在中和毒力方面能够取代精制破伤风抗毒素 ,可满足临床试验需求。
The toxin neutralizing activity was detected by human MAbs G2、G6、G2+G6 and horse anti tetanus antitoxin.The result showed that human MAbs G2、G6、G2+G6 were significantly higher than that of TAT.These human monoclonal antibodies were novel replacement for clinical trial.
出处
《微生物学免疫学进展》
2000年第1期58-59,共2页
Progress In Microbiology and Immunology
