卡维地洛对急性心肌梗死病人氧化应激及炎症因子的影响

Effects of Carvedilol on Oxidative Stress and Cytokines in Acute Myocardial Infarction

目的观察卡维地洛对急性心肌梗死病人氧化应激和炎症因子的影响。方法将115例急性心肌梗死病人随机分为卡维地洛组(65例)与对照组(50例),两组均予常规治疗,卡维地洛组加用卡维地洛12.5mg,2次/日,疗程4个月,并随访至半年。检测两组治疗前后氧化应激、炎症指标改变情况以及半年内的不良心血管事件。结果治疗后两组脂质过氧化物丙二醛(MDA)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)和超氧化物歧化酶(SOD)较治疗前显著改善(P<0.05或P<0.01),而卡维地洛组尤为明显(P<0.05)。与对照组比较,卡维地洛组的半年心血管不良事件发生率更低(P<0.05)。结论卡维地洛可显著降低急性心肌梗死病人氧化应激和血清炎症水平,减少心血管不良事件,对急性心肌梗死后的心脏发挥保护作用。

Objective To investigate the effects of carvedilol on oxidative stress and inflammatory cytokines in patients （pts） with acute myocardial infarction （AMI）. Methods One hundred and fifteen pts with AMI were randomly divided into carvedilol group （n=65） and control group （n= 50）. Each group was given traditional treatment. Carvedilol was additionally used for 4 months（12.5 mg, 2 times/d） in carvedilol group. The oxidative stress and inflammatory markers were detected in both groups before and after treatment. All pts were followed up for 6 months. Results After treatment, the lipid peroxide malonic aldehyde （MDA）, tumor necrosis factor （TNF-a） ,interleukin- 6 （IL- 6） and the superoxide dismutase （SOD） were improved（P〈0.05 or P〈0.01）, especially in the carvedilol group（P〈0.05）. Compare to the control group,lower cardiovascular adverse events were occurred in the carvedilol group （P〈0.05）. Conclusion Carvedilol could lower oxidative stress,serum level of inflammatory cytokine and reduce adverse cardiovascu- lar events in pts with AMI. It had protective effect on the heart after acute myocardial infarctory cytodines.